Endocrine Abstracts

Introduction: Follicular thyroid cancer (FTC) account for approximately 15% of all thyroid malignancies, with about 65 % being conventional and 35 % Huürthle cell type. Recently a PAX8-PPARγ gene fusion was detected in a significant portion of FTCs, some with a chromosomal translocation t(2;3)(q13;p25). The t(2;3) rearrangement leads to an in-frame fusion of the PAX8 gene, which encodes a transcription factor, with the peroxisome proliferator-activa...